I just went for my 3 month check up & my dr decided to put me on methotrexate along with plaquenil. I have to admit, I’m a little scared to take it but I’m also tired of hurting. I would appreciate any advise or input from those of you who are on methotrexate or have been on it.

I have been on methotrexate for over a year now. I was one of the lucky ones who had no side effects. It's been good to me, and I'm grateful. It definitely made an impact on my symptoms. I take folic acid with it, which helps counteract any nausea that may be associated with it. Be sure to ask your doc about it if they haven't mentioned it! As with any chemo drug, there also is the possibility of hair loss happening. Mine fluctuates, and I'm on other meds too, so it's hard to say (or remember) how much I had with just taking the methotrexate and prednisone. Best of luck hon. I know it's scary, but try not to let your fear keep you from feeling better. ::hugs:: Hang in there!

I have been taking methotrexate injections since May 2014. I took the pills for about three months prior too and didn't tolerate it at all. I hated taking that drug but. . .now I've gotten adjusted to it, I guess. I am extremely tired the day after and have some nausea once during the week but it has helped me to walk and get out of chairs. My joints were still swollen and painful so now I am about to start Orencia with it. I hope all goes well with you. Take care!

I was on Methotrexate and had all the side effects. I felt that this drug was going to kill me. I took the folic acid daily and still felt nauseous everyday, my liver enzymes were elevated, my hair was falling out, I was so tired and did not feel any better. I actually felt worse! I told my rheum that I was not suicidal but I would welcome death--he had to do something and do it quick. He took me off the methotrexate and plaquinil and started me on Enbrel. It was a life saver for me. I have energy, I have seen changes in what I thought were chronic malformations ,my pain is tolerable and my hair came back. I have been on Enbrel for 5 years now, with no side effects as of yet.

I do know people that swear by methotrexate and like we always say, everyone is an individual and medication affects everyone differently. Just be aware of how you are feeling and good luck.

Thanks to all of you for the input, it really means a lot to me.